Detailed view for PVX_084505

Basic information

TDR Targets ID: 265821
Plasmodium vivax, 3',5'-cyclic nucleotide phosphodiesterase, putative
Source Database / ID:  PlasmoDB 

pI: 7.3452 | Length (AA): 1005 | MW (Da): 115959 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5

Druggability Group : DG5

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00233   3'5'-cyclic nucleotide phosphodiesterase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004114   3',5'-cyclic-nucleotide phosphodiesterase activity  
GO:0003824   catalytic activity  
GO:0008081   phosphoric diester hydrolase activity  
GO:0007165   signal transduction  

Metabolic Pathways

Purine metabolism (KEGG)

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
649 997 1f0j (A) 152 508 27.00 0 1 0.8 -1.51
681 971 1zkl (A) 164 452 31.00 0 1 0.85 -1.93
686 942 1so2 (A) 695 999 32.00 0 1 0.66 -1.25
708 952 2h44 (A) 593 838 26.00 0 1 0.75 -1.66
12 188 2ap3 (A) 15 194 15.00 0.33 0.01 0.242719 -0.34
550 977 4wzi (B) 187 655 22.00 0 1 0.585671 0.18
557 947 4wzi (B) 167 627 29.00 0 0.99 0.623455 0.46
663 978 1zkl (A) 139 455 29.00 0 1 0.803228 -1.31
953 992 3qeh (H) 116 170 33.00 0.97 0.14 0.262601 0.59

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intraerythrocytic - 48 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intraerythrocytic - 36 hs, intraerythrocytic - 40 hs. Zhu L
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intraerythrocytic - 6 hs, intraerythrocytic - 12 hs, intraerythrocytic - 18 hs, intraerythrocytic - 24 hs, intraerythrocytic - 30 hs. Zhu L
Show/Hide expression data references
  • Zhu L New insights into the Plasmodium vivax transcriptome using RNA-Seq.

Orthologs

Ortholog group members (OG5_152655)

Species Accession Gene Product
Babesia bovis BBOV_IV010070   3'5'-cyclic nucleotide phosphodiesterase, putative
Plasmodium berghei PBANKA_0607900   3',5'-cyclic nucleotide phosphodiesterase, putative
Plasmodium falciparum PF3D7_1209500   cGMP-specific phosphodiesterase
Plasmodium knowlesi PKNH_1309400   3',5'-cyclic nucleotide phosphodiesterase, putative
Plasmodium vivax PVX_084505   3',5'-cyclic nucleotide phosphodiesterase, putative
Plasmodium yoelii PY01829   cGMP phosphodiesterase A4
Theileria parva TP01_0664   3',5' cyclic nucleotide phosphodiesterase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Plasmodium falciparum cGMP-specific phosphodiesterase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PVX_084505 (Plasmodium vivax), 3',5'-cyclic nucleotide phosphodiesterase, putative
Title for this comment
Comment